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Evaluation of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man

Abstract:

The management of atrial fibrillation remains a challenge. This condition remodels atrial electrical properties, which promote resistance to treatment. Although remodelling has long been a therapeutic target in atrial fibrillation, its causes remain incompletely understood. We aimed to evaluate the role of miR-31-dependent reduction in dystrophin and neuronal nitric oxide synthase (nNOS, also known as NOS1) on atrial electrical properties and atrial fibrillation inducibility.We recruited 258 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s0140-6736(15)60397-x

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author


Publisher:
Elsevier
Journal:
Lancet More from this journal
Volume:
385
Issue:
S1
Article number:
S82
Publication date:
2015-01-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736


Language:
English
Subtype:
Abstract
Pubs id:
pubs:541539
UUID:
uuid:013c1db8-c9f2-4b05-a1a1-f87aaed8068d
Local pid:
pubs:541539
Source identifiers:
541539
Deposit date:
2016-04-10

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