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Journal article

Leveraging a cloud-based critical care registry for COVID-19 pandemic surveillance and research in low- and middle-income countries

Abstract:
The COVID-19 pandemic has revealed limitations in real-time surveillance needed for responsive health care action in low- and middle-income countries (LMICs). The Pakistan Registry for Intensive CarE (PRICE) was adapted to enable International Severe Acute Respiratory and emerging Infections Consortium (ISARIC)–compliant real-time reporting of severe acute respiratory infection (SARI). The cloud-based common data model and standardized nomenclature of the registry platform ensure interoperability of data and reporting between regional and global stakeholders. Inbuilt analytics enable stakeholders to visualize individual and aggregate epidemiological, clinical, and operational data in real time. The PRICE system operates in 5 of 7 administrative regions of Pakistan. The same platform supports acute and critical care registries in eleven countries in South Asia and sub-Saharan Africa. ISARIC-compliant SARI reporting was successfully implemented by leveraging the existing PRICE infrastructure in all 49 member intensive care units (ICUs), enabling clinicians, operational leads, and established stakeholders with responsibilities for coordinating the pandemic response to access real-time information on suspected and confirmed COVID-19 cases (N=592 as of May 2020) via secure registry portals. ICU occupancy rates, use of ICU resources, mechanical ventilation, renal replacement therapy, and ICU outcomes were reported through registry dashboards. This information has facilitated coordination of critical care resources, health care worker training, and discussions on treatment strategies. The PRICE network is now being recruited to international multicenter clinical trials regarding COVID-19 management, leveraging the registry platform. Systematic and standardized reporting of SARI is feasible in LMICs. Existing registry platforms can be adapted for pandemic research, surveillance, and resource planning.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2196/21939

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Role:
Author
ORCID:
0000-0002-7332-0692
More by this author
Role:
Author
ORCID:
0000-0001-7046-1580
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Role:
Author
ORCID:
0000-0002-9476-839X
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-5190-2395


Publisher:
JMIR Publications
Journal:
JMIR Public Health and Surveillance More from this journal
Volume:
6
Issue:
4
Article number:
e21939
Publication date:
2020-11-23
Acceptance date:
2020-10-20
DOI:
EISSN:
2369-2960


Language:
English
Keywords:
Pubs id:
1139973
Local pid:
pubs:1139973
Deposit date:
2020-11-09

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