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Cyclic nucleotide signalling in cardiac myocytes from the mdx model of Duchenne muscular dystrophy

Abstract:

Background and Aims: Duchenne muscular dystrophy (DMD), the most frequent muscular dystrophy, is caused by mutations in the dystrophin gene resulting in the absence of dystrophin. Loss of cardiac dystrophin eventually leads to dilated cardiomyopathy and congestive heart failure in at least 20% of patients. Previous studies have shown that inhibition of enzymes that degrade cGMP improves cardiac contractility, energy metabolism and cardiac myocyte integrity in the DMD mou...

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Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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