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Phosphorylation of <i>Schizosaccharomyces pombe</i> Dss1 mediates direct binding to the ubiquitin‐ligase Dma1 in vitro

Abstract:

Intrinsically disordered proteins (IDPs) are often multifunctional and frequently posttranslationally modified. Deleted in split hand/split foot 1 (Dss1—Sem1 in budding yeast) is a highly multifunctional IDP associated with a range of protein complexes. However, it remains unknown if the different functions relate to different modified states. In this work, we show that Schizosaccharomyces pombe Dss1 is a substrate for casein kinase 2 in vitro, and we identify three phosphorylated threonines ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/pro.4733

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Role:
Author
ORCID:
0000-0002-8264-0057
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Role:
Author
ORCID:
0000-0001-9471-3420
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Role:
Author
ORCID:
0000-0003-1975-952X
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Role:
Author
ORCID:
0000-0002-7434-9737
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-1506-4280


Publisher:
Wiley
Journal:
Protein Science More from this journal
Volume:
32
Issue:
9
Pages:
e4733-e4733
Publication date:
2023-07-18
DOI:
EISSN:
1469-896X
ISSN:
0961-8368


Language:
English
Keywords:
Pubs id:
2370906
Local pid:
pubs:2370906
Source identifiers:
W4384627181
Deposit date:
2026-02-13
ARK identifier:
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