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Journal article

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.

Abstract:

BACKGROUND: Existing methods of non-viral airway gene transfer suffer from low levels of efficiency. Electroporation has been used to enhance gene transfer in a range of tissues. Here we assess the usefulness of electroporation for enhancing gene transfer in the lungs of mice and sheep. METHODS: Naked plasmid DNA (pDNA) expressing either luciferase or green fluorescent protein (GFP) was delivered to mouse lungs by instillation. Following surgical visualisation, the lungs were directly electr...

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Publication status:
Published

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Publisher copy:
10.1002/jgm.1026

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Journal:
The journal of gene medicine
Volume:
9
Issue:
5
Pages:
369-380
Publication date:
2007-05-05
DOI:
EISSN:
1521-2254
ISSN:
1099-498X
URN:
uuid:0127f6f8-e112-4da6-b0d7-f1adb7fb2194
Source identifiers:
15663
Local pid:
pubs:15663

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