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The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia.

Abstract:

The clinical features of the maternal syndrome of pre-eclampsia can be explained by generalised maternal endothelial cell dysfunction, which is a part of a more global maternal systemic inflammatory response. There is growing evidence that these effects are associated with the shedding of cellular debris, including syncytiotrophoblast microparticles (STBM), cell-free DNA and mRNA, from the surface of the placenta (syncytiotrophoblast) into the maternal circulation. The increased shedding of t...

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Publication status:
Published

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Journal:
Placenta
Volume:
29
Issue:
11
Pages:
942-949
Publication date:
2008-11-05
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
URN:
uuid:011a51b8-f40f-45e9-b662-39d0f040cade
Source identifiers:
248235
Local pid:
pubs:248235

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