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The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes

Abstract:

Adult mammalian ventricular cardiomyocytes are terminally differentiated cells that enlarge adaptively by hypertrophy. In this situation, genes normally expressed in the fetal ventricular cardiomyocyte (e.g. atrial natriuretic factor (ANF), beta-myosin heavy chain (beta-MHC), and skeletal muscle (SkM) alpha-actin) are re-expressed, and there is transient expression of immediate early genes (e.g. c-fos). Using appropriate reporter plasmids, we studied the effects of transfection of the constit...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.270.47.28092

Authors


Gillespie-Brown, J More by this author
Fuller, SJ More by this author
Bogoyevitch, MA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Sugden, PH More by this author
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
270
Issue:
47
Pages:
28092-28096
Publication date:
1995-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:0115950b-371d-4a5b-8df4-7e2ebe9197ae
Source identifiers:
223740
Local pid:
pubs:223740

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