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Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors.

Abstract:

Serotonin has a facilitatory role in the role of prolactin and adrenocorticotropin (ACTH) secretion. The serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) dose dependently (30-100 mg/kg i.p.) increased plasma prolactin and ACTH in the male rat. Prolactin and ACTH responses to 5-HTP (100 mg/kg) were attenuated by pretreatment with the non-selective 5-HT receptor antagonist, metergoline (0.5 mg/kg), and by the selective 5-HT2 receptor antagonists, ritanserin (0.4 mg/kg), ketanserin (2.5 mg/kg)...

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Publication status:
Published

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Journal:
European journal of pharmacology
Volume:
179
Issue:
1-2
Pages:
103-109
Publication date:
1990-04-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:0114059b-4f7f-40bf-bd4d-b67dfbc79e46
Source identifiers:
185829
Local pid:
pubs:185829

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