Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors.

Journal article

Serotonin has a facilitatory role in the role of prolactin and adrenocorticotropin (ACTH) secretion. The serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) dose dependently (30-100 mg/kg i.p.) increased plasma prolactin and ACTH in the male rat. Prolactin and ACTH responses to 5-HTP (100 mg/kg) were attenuated by pretreatment with the non-selective 5-HT receptor antagonist, metergoline (0.5 mg/kg), and by the selective 5-HT2 receptor antagonists, ritanserin (0.4 mg/kg), ketanserin (2.5 mg/kg), ICI (5.0 mg/kg) and spiperone (1.0 mg/kg). The 5-HT1 receptor antagonists, propranolol (40 mg/kg) and pindolol (4.0 mg/kg), failed to antagonize the prolactin and ACTH responses to 5-HTP (100 mg/kg), as did the selective 5-HT3 receptor antagonist, BRL 43694 (1.0 mg/kg). The results suggest that the prolactin and ACTH responses to 5-HTP in the male rat are mediated by 5-HT2 receptors.

Authors: Gartside, SE; Cowen, P

• Publication status: Published
• Journal: European journal of pharmacology
• Volume: 179
• Issue: 1-2
• Pages: 103-109
• Publication date: 1990-04-01
• DOI: 10.1016/0014-2999(90)90407-w
• EISSN: 1879-0712
• ISSN: 0014-2999
• Language: English
• Keywords: Dose-Response Relationship, Drug; Adrenocorticotropic Hormone; Piperidines; Ritanserin; Serotonin Antagonists; 5-Hydroxytryptophan; Spiperone; Metergoline; Prolactin; Animals; Male; Ketanserin; Receptors, Serotonin; Rats, Inbred Strains; Rats