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Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation.

Abstract:

The expression of interferon-β (IFN-β) in virus-infected HeLa cells established a paradigm of multifactorial gene regulation, in which cooperative assembly of transcription factors (TFs) at the composite DNA element (enhanceosome), is central for amplification of weak activating signals provided by individual TFs. However, whether the same TFs and the same DNA element are essential for IFN-β induction in response to bacterial stimuli are less well understood. Here we report that rapid and tra...

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Publication status:
Published

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Journal:
Blood
Volume:
116
Issue:
25
Pages:
5580-5588
Publication date:
2010-12-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
110406

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