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Birthweight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis.

Abstract:

OBJECTIVE: To investigate risk factors for adult lumbar spine osteoarthritis (OA) including polymorphisms of the vitamin D receptor gene (VDR) and birthweight. METHODS: Plain radiographs of the lumbar spine were taken in 392 healthy subjects and graded for osteophytes and disc space narrowing (DSN); demographic data were collected. Details of birthweight and weight at 1 year were retrieved from historical records. VDR gene allelic variation was analyzed in 291 subjects. RESULTS: The mean age...

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Publication status:
Published

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Authors


Jordan, KM More by this author
Syddall, H More by this author
Dennison, EM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
The Journal of rheumatology
Volume:
32
Issue:
4
Pages:
678-683
Publication date:
2005-04-05
ISSN:
0315-162X
URN:
uuid:010720b8-1cfe-4474-beb7-9153735ede9d
Source identifiers:
125668
Local pid:
pubs:125668

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