Journal article

Silicon incorporated morpholine antifungals: Design, synthesis, and biological evaluation

Abstract:: Known morpholine class antifungals (fenpropimorph, fenpropidin, and amorolfine) were synthetically modified through silicon incorporation to have 15 sila-analogues. Twelve sila-analogues exhibited potent antifungal activity against different human fungal pathogens such as Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans, and Aspergillus niger. Sila-analogue 24 (fenpropimorph analogue) was the best in our hands, which showed superior fungicidal potential than fenpropidin, fenpropimorph, and amorolfine. The mode of action of sila-analogues was similar to morpholines, i.e., inhibition of sterol reductase and sterol isomerase enzymes of ergosterol synthesis pathway.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Jachak, G. R., Ramesh, R., Sant, D. G., Jorwekar, S. U., Jadhav, M. R., Tupe, S. G., Deshpande, M. V., & Reddy, D. S. (2015). Silicon incorporated morpholine antifungals: Design, synthesis, and biological evaluation. ACS Medicinal Chemistry Letters, 6(11), 1111–1116.

MLA Style

Jachak, G. R., et al. “Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation.” ACS Medicinal Chemistry Letters, vol. 6, no. 11, American Chemical Society, 2015, pp. 1111–16.

Chicago Style

Jachak, GR, R Ramesh, DG Sant, SU Jorwekar, MR Jadhav, SG Tupe, MV Deshpande, and DS Reddy. 2015. “Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation.” ACS Medicinal Chemistry Letters 6 (11): 1111–16.
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Publisher copy:: 10.1021/acsmedchemlett.5b00245

Authors

+ Jachak, GR More by this author

Role:: Author

+ Ramesh, R More by this author

Role:: Author

+ Sant, DG More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Biology
Role:: Author

+ Jorwekar, SU More by this author

Role:: Author

+ Jadhav, MR More by this author

Role:: Author

More authors...

Publisher:: American Chemical Society
Journal:: ACS Medicinal Chemistry Letters More from this journal
Volume:: 6
Issue:: 11
Pages:: 1111-1116
Publication date:: 2015-09-22
Acceptance date:: 2015-09-22
DOI:: 10.1021/acsmedchemlett.5b00245
ISSN:: 1948-5875

Language:: English
Keywords:: FFR
Pubs id:: 1278491
Local pid:: pubs:1278491
Deposit date:: 2022-09-12

Terms of use

Copyright holder:: American Chemical Society
Copyright date:: 2015
Rights statement:: Copyright © 2015 American Chemical Society

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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