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Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs.

Abstract:

Diamond-Blackfan anemia (DBA) is a disorder characterized by a selective defect in erythropoiesis. Delineation of the precise defect is hampered by a lack of markers that define cells giving rise to erythroid burst- and erythroid colony-forming unit (BFU-E and CFU-E) colonies, the clonogenic assays that quantify early and late erythroid progenitor (EEP and LEP) potential, respectively. By combining flow cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD3...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Iskander, D More by this author
Gerrard, G More by this author
Chaidos, A More by this author
En Foong, H More by this author
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Imperial College Healthcare National Health Service Trust More from this funder
CHAMPS charity More from this funder
National Institute for Health Research More from this funder
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
125
Issue:
16
Pages:
2553-2557
Publication date:
2015
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:00f929f3-6976-4235-83cd-63970e46a5f0
Source identifiers:
510089
Local pid:
pubs:510089

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