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MRI as an outcome in multiple sclerosis clinical trials.

Abstract:

INTRODUCTION: T2-weighted and gadolinium enhanced T1-weighted MRI scans measure plaque burden and breakdown of the blood-brain barrier, respectively, in multiple sclerosis (MS) lesions. These have become widely used outcome measures for monitoring disease activity in clinical trials and clinical practice. However, their use as surrogates or biomarkers for disability and relapses, key clinical outcome measures, has remained incompletely validated. METHODS: In a clinical trial database compris...

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Publication status:
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Authors


Neuhaus, A More by this author
Morrissey, S More by this author
Hintzen, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Journal:
Neurology
Volume:
72
Issue:
8
Pages:
705-711
Publication date:
2009-02-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:00f8b9fa-bcad-4c22-8b92-72d907ef72df
Source identifiers:
34517
Local pid:
pubs:34517

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