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Journal article

Epigenetic gene promoter methylation at birth is associated with child's later adiposity.

Abstract:

OBJECTIVE: Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans. RESEARCH DESIGN AND METHODS: Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5' from five candidate genes in umbilical cord tissue DNA from healthy neonates. Methylation varied greatly at...

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Publication status:
Published

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Publisher copy:
10.2337/db10-0979

Authors


Godfrey, KM More by this author
Sheppard, A More by this author
Gluckman, PD More by this author
Lillycrop, KA More by this author
Burdge, GC More by this author
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Journal:
Diabetes
Volume:
60
Issue:
5
Pages:
1528-1534
Publication date:
2011-05-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:00f01bf2-79d9-4316-a06c-bccc12408ab3
Source identifiers:
131250
Local pid:
pubs:131250

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