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Journal article

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation.

Abstract:

Osteocytes are the most abundant cells in bone and are ideally located to influence bone turnover through their syncytial relationship with surface bone cells. Osteocyte-derived signals have remained largely enigmatic, but it was recently reported that human osteocytes secrete sclerostin, an inhibitor of bone formation. Absent sclerostin protein results in the high bone mass clinical disorder sclerosteosis. Here we report that within adult iliac bone, newly embedded osteocytes were negative f...

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Publication status:
Published

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Publisher copy:
10.1096/fj.05-4221fje

Authors


van Bezooijen, RL More by this author
Loveridge, N More by this author
Hamersma, H More by this author
Papapoulos, SE More by this author
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
19
Issue:
13
Pages:
1842-1844
Publication date:
2005-11-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:00edd85a-8457-4e18-bbda-2ec196470a92
Source identifiers:
473618
Local pid:
pubs:473618

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