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Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer.

Abstract:

Whereas a recent study reported an increased risk of colorectal cancer associated with any HFE germ line mutation (C282Y or H63D), other investigators have concluded there is no increased risk, or that any increase is dependent on polymorphisms in HFE-interacting genes such as the transferrin receptor (TFR). We have established the frequency of HFE mutations in colorectal cancer patients (n = 327) with a family history of the disease and randomly selected controls (n = 322); this design incre...

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Authors


Robinson, JP More by this author
Johnson, VL More by this author
Rogers, PA More by this author
Houlston, RS More by this author
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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
14
Issue:
6
Pages:
1460-1463
Publication date:
2005-06-05
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
URN:
uuid:00e861c2-2011-4ad0-bf34-5bf8f478bd7c
Source identifiers:
72239
Local pid:
pubs:72239

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