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Journal article

The contribution of functional antimalarial immunity to measures of parasite clearance in therapeutic efficacy studies of artemisinin derivatives

Abstract:

Background

Antibodies to the blood stages of malaria parasites enhance parasite clearance and antimalarial efficacy. The antibody subclass and functions that contribute to parasite clearance during antimalarial treatment and their relationship to malaria transmission intensity have not been characterized.

Methods

Levels of immunoglobulin G (IgG) subclasses and C1q fixation in response to Plasmodium falciparum merozoite antigens (erythrocyte-binding antigen [EBA] 175RIII-V, mero... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/infdis/jiz247

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-7620-4822
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
220
Issue:
7
Pages:
1178–1187
Publication date:
2019-05-10
Acceptance date:
2019-05-09
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
31075171
Source identifiers:
998451
Language:
English
Keywords:
Pubs id:
pubs:998451
UUID:
uuid:00ded025-7331-4d27-92c5-76de0acdf4b8
Local pid:
pubs:998451
Deposit date:
2019-06-14

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