Journal article
Selective deprotection strategies to N-(alpha-methylbenzyl)-beta-amino esters and derived beta lactams
- Abstract:
- A variety of N,N-diprotected β-amino esters, prepared by highly diastereoselective conjugate addition of chiral lithium amides, were selectively mono-deprotected under either reductive (hydrogenolysis) or oxidative (DDQ or CAN) conditions. Combined with these deprotection methods, lithium (α-methylbenzyl)(3,4-dimethoxybenzyl) amide 2 can be used as an efficient differentially protected chiral ammonia equivalent for the asymmetric synthesis of β-amino acid and β-lactam derivatives.
- Publication status:
- Published
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- Publisher copy:
- 10.1016/S0040-4039(98)01193-9
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Authors
Bibliographic Details
- Journal:
- TETRAHEDRON LETTERS
- Volume:
- 39
- Issue:
- 33
- Pages:
- 6045-6048
- Publication date:
- 1998-08-13
- DOI:
- ISSN:
-
0040-4039
- Source identifiers:
-
110630
Item Description
- Language:
- English
- Pubs id:
-
pubs:110630
- UUID:
-
uuid:00d352cb-b141-4d78-a8e7-a84cd4ce491b
- Local pid:
- pubs:110630
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1998
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