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Is H3K4me3 instructive for transcription activation?

Abstract:

Tri-methylation of lysine 4 on histone H3 (H3K4me3) is a near-universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an 'activating' histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from geno...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/bies.201600095

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Grant:
WT089156MA; 097302/Z/11/Z
Publisher:
Wiley Publisher's website
Journal:
BioEssays Journal website
Volume:
39
Issue:
1
Pages:
1-12
Publication date:
2017-01-05
Acceptance date:
2016-10-14
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
Pubs id:
pubs:667276
URN:
uri:00d182ab-a2ca-4d1c-b24f-58858b668cf6
UUID:
uuid:00d182ab-a2ca-4d1c-b24f-58858b668cf6
Local pid:
pubs:667276
Paper number:
1

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