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Is H3K4me3 instructive for transcription activation?

Abstract:

Tri-methylation of lysine 4 on histone H3 (H3K4me3) is a near-universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an 'activating' histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from geno...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bies.201600095

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Grant:
WT089156MA; 097302/Z/11/Z
Publisher:
Wiley Publisher's website
Journal:
BioEssays Journal website
Volume:
39
Issue:
1
Pages:
1-12
Publication date:
2017-01-01
Acceptance date:
2016-10-14
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
Source identifiers:
667276
Language:
English
Keywords:
Pubs id:
pubs:667276
UUID:
uuid:00d182ab-a2ca-4d1c-b24f-58858b668cf6
Local pid:
pubs:667276
Deposit date:
2017-01-11

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