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The impact of different CD4 cell-count monitoring and switching strategies on mortality in HIV-infected African adults on antiretroviral therapy: an application of dynamic marginal structural models

Abstract:

In Africa, antiretroviral therapy (ART) is delivered with limited laboratory monitoring, often none. In 2003-2004, investigators in the Development of Antiretroviral Therapy in Africa (DART) Trial randomized persons initiating ART in Uganda and Zimbabwe to either laboratory and clinical monitoring (LCM) or clinically driven monitoring (CDM). CD4 cell counts were measured every 12 weeks in both groups but were only returned to treating clinicians for management in the LCM group. Follow-up cont...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/aje/kwv083

Authors


Deborah Ford More by this author
James M. Robins More by this author
More by this author
Department:
NDM Experimental Medicine, University of Oxford
Maya L. Petersen More by this author
Diana M. Gibb More by this author
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Publisher:
Oxford University Press Publisher's website
Journal:
American Journal of Epidemiology
Volume:
182
Issue:
7
Pages:
633-643
Publication date:
2015-08-26
Acceptance date:
2015-03-27
DOI:
EISSN:
1476-6256
ISSN:
0002-9262

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