Journal article
P2X6 knockout mice exhibit normal electrolyte homeostasis
- Abstract:
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ATP-mediated signaling is an important regulator of electrolyte transport in the kidney. The purinergic cation channel P2X6 has been previously localized to the distal convoluted tubule (DCT), a nephron segment important for Mg2+ and Na+ reabsorption, but its role in ion transport remains unknown. In this study, P2x6 knockout (P2x6-/-) mice were generated to investigate the role of P2X6 in renal electrolyte transport. The P2x6-/- animals displayed a normal phenotype and did not differ physiol...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.5MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0156803
Authors
Funding
+ Dutch Kidney Foundation
More from this funder
Funding agency for:
De Baaij, J
Grant:
Kolff 14OKG17
+ Netherlands Organization for Scientific Research
More from this funder
Funding agency for:
De Baaij, J
Grant:
Kolff 14OKG17
NWO VICI 016.130.668
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS ONE More from this journal
- Volume:
- 11
- Issue:
- 6
- Article number:
- e0156803
- Publication date:
- 2016-06-02
- Acceptance date:
- 2016-05-19
- DOI:
- ISSN:
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1932-6203
- Pmid:
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27254077
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
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pubs:633120
- UUID:
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uuid:00b0043b-9dcb-4c1f-ad6d-9dba7ef2dc76
- Local pid:
-
pubs:633120
- Source identifiers:
-
633120
- Deposit date:
-
2018-08-08
Terms of use
- Copyright holder:
- © 2016 de Baaij et al
- Copyright date:
- 2016
- Notes:
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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