Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption.

Journal article

We investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)-treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10. Plasma IL-10 levels were not significantly increased postvaccination, but increased in parallel with viraemia in patients who interrupted therapy. Surprisingly, IL-10 blockade augmented HIV-specific T cell proliferative responses in HAART-suppressed patients but had no effect once virological control was lost. Modulation of IL-10 might enhance vaccine-induced immune responses.

Authors: Yang, H; Guimarães-Walker, A; Hibbs, S; Dong, T; Stacey, A

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 23
• Issue: 16
• Pages: 2226-2230
• Publication date: 2009-10-01
• DOI: 10.1097/qad.0b013e328331a424
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: Anti-HIV Agents; HIV-1; RNA, Viral; Humans; AIDS Vaccines; Antiretroviral Therapy, Highly Active; Interleukin-10; Viral Load; HIV Infections