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Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase.

Abstract:

BNIP3 is a hypoxia-inducible BH3-only member of the Bcl-2 family of proteins that regulate apoptosis and autophagy. However the role of BNIP3 in the hypoxia response has proved difficult to define and remains controversial. In this study we show that in cancer cells, knockdown or forced expression of BNIP3 fails to modulate cell survival under hypoxic or normoxic conditions. However, we demonstrate that BNIP3 is regulated post-translationally, existing as multiple monomeric and dimeric phosph...

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Publication status:
Published

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Publisher copy:
10.1016/j.bcp.2010.01.019

Authors


Mellor, HR More by this author
Rouschop, KM More by this author
Wigfield, SM More by this author
Wouters, BG More by this author
Harris, AL More by this author
Journal:
Biochemical pharmacology
Volume:
79
Issue:
11
Pages:
1562-1572
Publication date:
2010-06-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:009e4980-8862-4e09-9baa-3a2eee533ab0
Source identifiers:
125249
Local pid:
pubs:125249

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