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Journal article

Elimination of the immunogenicity of therapeutic antibodies.

Abstract:

The immunogenicity of therapeutic Abs limits their long-term use. The processes of complementarity-determining region grafting, resurfacing, and hyperchimerization diminish mAb immunogenicity by reducing the number of foreign residues. However, this does not prevent anti-idiotypic and anti-allotypic responses following repeated administration of cell-binding Abs. Classical studies have demonstrated that monomeric human IgG is profoundly tolerogenic in a number of species. If cell-binding Abs ...

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Publication status:
Published

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Journal:
Journal of Immunology
Volume:
162
Issue:
6
Pages:
3663-3671
Publication date:
1999-03-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
16882

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