Journal article
Elimination of the immunogenicity of therapeutic antibodies.
- Abstract:
-
The immunogenicity of therapeutic Abs limits their long-term use. The processes of complementarity-determining region grafting, resurfacing, and hyperchimerization diminish mAb immunogenicity by reducing the number of foreign residues. However, this does not prevent anti-idiotypic and anti-allotypic responses following repeated administration of cell-binding Abs. Classical studies have demonstrated that monomeric human IgG is profoundly tolerogenic in a number of species. If cell-binding Abs ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 162
- Issue:
- 6
- Pages:
- 3663-3671
- Publication date:
- 1999-03-01
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
16882
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:16882
- UUID:
-
uuid:0098fc57-366e-421c-9143-99df5c661f31
- Local pid:
- pubs:16882
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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