Journal article
Technical challenges of working with extracellular vesicles
- Abstract:
- Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1039/c7nr08360b
Authors
+ CNPq Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
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- Grant:
- 202077/2015-2
+ Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
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- Grant:
- 2014/06863-3
- Publisher:
- Royal Society of Chemistry
- Journal:
- Nanoscale More from this journal
- Volume:
- 10
- Issue:
- 3
- Pages:
- 881-906
- Publication date:
- 2017-12-13
- Acceptance date:
- 2017-12-08
- DOI:
- EISSN:
-
2040-3372
- ISSN:
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2040-3364
- Pmid:
-
29265147
- Language:
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English
- Pubs id:
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pubs:812824
- UUID:
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uuid:008b4a7c-d99c-4a85-9753-529ba3d63b87
- Local pid:
-
pubs:812824
- Source identifiers:
-
812824
- Deposit date:
-
2018-04-09
- ARK identifier:
Terms of use
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2017
- Notes:
- Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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