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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.

Abstract:

In recent years, small protein oligomers have been implicated in the aetiology of a number of important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's disease. As a consequence, research efforts are being directed away from traditional targets, such as amyloid plaques, and towards characterization of early oligomer states. Here we present a new analysis method, ion mobility coupled with mass spectrometry, for this challenging problem, which allows determination...

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Publication status:
Published

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Publisher copy:
10.1038/nchem.247

Authors


Bernstein, SL More by this author
Dupuis, NF More by this author
Wyttenbach, T More by this author
Condron, MM More by this author
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Journal:
Nature chemistry
Volume:
1
Issue:
4
Pages:
326-331
Publication date:
2009-07-05
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
URN:
uuid:00783661-3665-4c26-92b8-783542c2a8f3
Source identifiers:
59399
Local pid:
pubs:59399

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