Finding the right balance: a personal journey from individual proteins to membrane-embedded motors: based on a lecture delivered at the 36th FEBS Congress in Torino, Italy, June 2011.
It is now more than 20 years since the prophetic words of John Fenn, announcing his discovery, stated that 'Electrospray spectra have been obtained for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130 000, with as yet no evidence of an upper limit' (Fenn JB, Mann M, Kai Meng C, Fu Wong S and Whitehouse CM (1989) Science246, 64-71). Today, with the mass spectra of intact ribosomes at 2.3 MDa becoming almost routine and the first electrospray sp...Expand abstract
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