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Evolutionary history of Salmonella typhi.

Abstract:

For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still pers...

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Publication status:
Published

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Publisher copy:
10.1126/science.1134933

Authors


Roumagnac, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Science (New York, N.Y.)
Volume:
314
Issue:
5803
Pages:
1301-1304
Publication date:
2006-11-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:0069fdb4-de17-4a27-8493-850dc5b4dc83
Source identifiers:
40200
Local pid:
pubs:40200

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