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A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

Abstract:

The glycan shield of human immunodeficiency virus type 1 (HIV-1) gp120 contributes to viral evasion from humoral immune responses. However, the shield is recognized by the HIV-1 broadly neutralizing antibody (Ab), 2G12, at a relatively conserved cluster of oligomannose glycans. The discovery of 2G12 raises the possibility that a carbohydrate immunogen may be developed that could elicit 2G12-like neutralizing Abs and contribute to an AIDS vaccine. We have previously dissected the fine specific...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00293-08

Authors


Astronomo, RD More by this author
Scanlan, CN More by this author
Pantophlet, R More by this author
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Journal:
Journal of virology
Volume:
82
Issue:
13
Pages:
6359-6368
Publication date:
2008-07-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:0062730f-518a-4ef2-a3f1-b841f159e89d
Source identifiers:
101080
Local pid:
pubs:101080

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