Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: a double-blind randomized controlled trial.

Journal article

Bites by many species of venomous snake may result in local necrosis at, or extending from, the site of the bite. The use of prophylactic antibiotics to prevent infection as a complication of local necrotic envenoming is controversial. A double-blind randomized controlled trial was carried out to assess whether antibiotic therapy is effective in this situation. Two hundred and fifty-one patients, with proven envenoming by snakes of the genus Bothrops, admitted to two hospitals in Brazil, betw...

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Authors: Jorge, M; Malaque, C; Ribeiro, L; Fan, H; Cardoso, J

• Publication status: Published
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
• Volume: 98
• Issue: 9
• Pages: 529-534
• Publication date: 2004-09-01
• DOI: 10.1016/j.trstmh.2003.12.009
• EISSN: 1878-3503
• ISSN: 0035-9203
• Language: English
• Keywords: Humans; Animals; Anti-Bacterial Agents; Middle Aged; Treatment Outcome; Female; Child; Male; Bothrops; Adolescent; Snake Bites; Administration, Oral; Abscess; Chloramphenicol; Child, Preschool; Double-Blind Method; Adult; Necrosis; Infant; Brazil