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The pharmacokinetics and acceptability of lopinavir/ritonavir minitab sprinkles, tablets, and syrups in african HIV-infected children.

Abstract:

BACKGROUND: Guidelines recommend lopinavir/ritonavir (LPV/r) as first- and second-line therapy for young and older HIV-infected children, respectively. Available formulations have limitations making their widespread use complex. METHODS: An open-label comparative bioavailability (randomized crossover) study compared a novel twice-daily minitab sprinkle formulation (40 mg/10 mg, Cipla Pharmaceuticals) versus innovator syrup in HIV-infected Ugandan infants aged 3 to <12 months (cohort A) and...

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Publication status:
Published

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Authors


Musiime, V More by this author
Fillekes, Q More by this author
Kekitiinwa, A More by this author
Kendall, L More by this author
Keishanyu, R More by this author
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Publisher:
Lippincott Williams and Wilkins
Journal:
Journal of acquired immune deficiency syndromes (1999)
Volume:
66
Issue:
2
Pages:
148-154
Publication date:
2014-06-05
DOI:
EISSN:
1944-7884
ISSN:
1525-4135
URN:
uuid:00552868-0aae-4e46-8d97-043bd4163e75
Source identifiers:
466264
Local pid:
pubs:466264

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