Journal article
Risk of new-onset long COVID following reinfection with SARS-CoV-2: community-based cohort study
- Abstract:
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Background
Little is known about the risk of long COVID following reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We estimated the likelihood of new-onset, self-reported long COVID after a second SARS-CoV-2 infection, compared to a first infection.Methods
We included UK COVID-19 Infection Survey participants who tested positive for SARS-CoV-2 between 1 November 2021 and 8 October 2022. The primary outcome was self-reported long COVID 12–20 weeks after each infection. Separate analyses were performed for those <16 years and ≥16 years. We estimated adjusted odds ratios (aORs) for new-onset long COVID using logistic regression, comparing second to first infections, controlling for sociodemographic characteristics and calendar date of infection, plus vaccination status in participants ≥16 years of age.Results
Overall, long COVID was reported by those ≥16 years after 4.0% and 2.4% of first and second infections, respectively; the corresponding estimates among those aged <16 years were 1.0% and 0.6%. The aOR for long COVID after second compared to first infections was 0.72 (95% confidence interval [CI], .63–.81) for those ≥16 years and 0.93 (95% CI, .57–1.53) for those <16 years.Conclusions
The risk of new-onset long COVID after a second SARS-CoV-2 infection is lower than that after a first infection for persons aged ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset long COVID after a second infection, with around 1 in 40 of those aged ≥16 years and 1 in 165 of those <16 years reporting long COVID after a second infection.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 797.8KB, Terms of use)
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- Publisher copy:
- 10.1093/ofid/ofad493
Authors
- Publisher:
- Oxford University Press
- Journal:
- Open Forum Infectious Diseases More from this journal
- Volume:
- 10
- Issue:
- 11
- Article number:
- ofad493
- Publication date:
- 2023-10-05
- Acceptance date:
- 2023-10-02
- DOI:
- EISSN:
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2328-8957
- Language:
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English
- Keywords:
- Pubs id:
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1541163
- Local pid:
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pubs:1541163
- Deposit date:
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2023-10-05
Terms of use
- Copyright holder:
- Bosworth et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Notes:
- For the purpose of open access, the authors have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.
- Licence:
- CC Attribution (CC BY)
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