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Inflammation versus neurodegeneration: consequences for treatment.

Abstract:

Inflammation is assumed to be the main driver of neurodegeneration in multiple sclerosis. However there is evidence that questions this hypothesis: Data from pathological studies and from imaging have shown that neuronal/axonal damage occurs early in lesion formation and at the earliest clinical stage of the disease. Additionally axonal damage itself can lead to inflammation and laboratory and clinical observations suggest that inflammation may be neuroprotective. Finally, clinical trials rev...

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Publication status:
Published

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Publisher copy:
10.1016/j.jns.2006.05.072

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of the neurological sciences
Volume:
259
Issue:
1-2
Pages:
46-49
Publication date:
2007-08-05
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
URN:
uuid:004e565c-e936-40d4-87d3-47d7bc76cdc8
Source identifiers:
242011
Local pid:
pubs:242011

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