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S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization.

Abstract:

The present studies characterized the functional profile of N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-1,2-dihydro-3-H-benzo[e]indole-3-carboxamide) (S32212), a combined serotonin (5-HT)(2C) receptor inverse agonist and α(2)-adrenoceptor antagonist that also possesses 5-HT(2A) antagonist properties (J Pharmacol Exp Ther 340:750-764, 2012). Upon parenteral and/or oral administration, dose-dependent (0.63-40.0 mg/kg) actions were observed in diverse procedures. Both acute and subchronic adm...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.111.187534

Authors


Dekeyne, A More by this author
Loiseau, F More by this author
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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
340
Issue:
3
Pages:
765-780
Publication date:
2012-03-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:004b9118-50ff-4caf-af40-dc95f7f3e903
Source identifiers:
267228
Local pid:
pubs:267228

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