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Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases.

Abstract:

A distinctive feature in the topographic organization of the olfactory system in mammals is the dual function of the odorant receptor (OR): it detects odors in the nasal epithelium and plays an instructive role in the axonal convergence of olfactory sensory neurons (OSN) into the olfactory bulb (OB). The latter function is supported by genetic experiments and by the expression of the OR not only on the cilia, but also on the axon termini of the OSN. The signaling pathway coupled to the OR on ...

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Publisher copy:
10.1073/pnas.0813224106

Authors


Maritan, M More by this author
Zamparo, I More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
9
Pages:
3537-3542
Publication date:
2009-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:003d8dc5-c7b1-4162-a802-86de7d69339f
Source identifiers:
237065
Local pid:
pubs:237065

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