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A silent deletion in the beta-globin gene cluster.

Abstract:

A survey of the gamma-globin gene region of over 1000 normal individuals revealed a novel 2.5 kb deletion which removes the 5' end of the A gamma-globin gene. Unusually, this deletion in the beta-globin gene cluster is not associated with increased fetal haemoglobin production. Sequence analysis of the deletion endpoints revealed no significant homology at the breakpoint and failed to support a role for a proposed recombination hotspot in IVS-2 in the generation of this illegitimate recombina...

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Publication status:
Published

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Publisher copy:
10.1093/nar/14.12.4743

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Bowden, DK More by this author
Sadler, JR More by this author
Weatherall, DJ More by this author
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Journal:
Nucleic acids research
Volume:
14
Issue:
12
Pages:
4743-4750
Publication date:
1986-06-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:003b4ffe-0c33-4764-b59d-350574996c30
Source identifiers:
53934
Local pid:
pubs:53934

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