Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells.

Journal article

D-glucose reduces the outflow of manganese from pancreatic beta-cells in analogy to what has previously been reported for 45Ca. The decrease can be accounted for by an enhanced intracellular sequestration. The effect of D-glucose on manganese fluxes seems to be restricted to inhibition of the efflux; no stimulation of the influx being noted. The glucose-dependence of manganese uptake is hyperbolic with half maximal stimulation between 5 and 6 mM D-glucose.

Authors: Rorsman, P

• Publication status: Published
• Journal: Acta biologica et medica Germanica
• Volume: 41
• Issue: 12
• Pages: 1221-1224
• Publication date: 1982-01-01
• ISSN: 0001-5318
• Language: English
• Keywords: Glucose; Calcium; Islets of Langerhans; Manganese