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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Abstract:

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Co...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-07340-5

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Role:
Author
ORCID:
0000-0003-2786-1225
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Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 5141
Publication date:
2018-12-03
Acceptance date:
2018-09-24
DOI:
EISSN:
2041-1723
Pubs id:
pubs:950584
URN:
uri:0035f03f-fd0a-447f-99bd-8f782ce2d6e7
UUID:
uuid:0035f03f-fd0a-447f-99bd-8f782ce2d6e7
Local pid:
pubs:950584

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