- Abstract:
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Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Co...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.6MB)
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- Publisher copy:
- 10.1038/s41467-018-07340-5
-
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- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Pages:
- Article: 5141
- Publication date:
- 2018-12-03
- Acceptance date:
- 2018-09-24
- DOI:
- EISSN:
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2041-1723
- Pubs id:
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pubs:950584
- URN:
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uri:0035f03f-fd0a-447f-99bd-8f782ce2d6e7
- UUID:
-
uuid:0035f03f-fd0a-447f-99bd-8f782ce2d6e7
- Local pid:
- pubs:950584
- Language:
- English
- Keywords:
- Copyright holder:
- Franceschini et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Journal article
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
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