- Abstract:
-
We have used DNase I footprinting, fluorescence and ultraviolet (UV) melting experiments and circular dichroism to demonstrate that, in the parallel triplex binding motif, 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine (bis-amino-U, BAU) has very high affinity for AT relative to all other Watson-Crick base pairs in DNA. Complexes containing two or more substitutions with this nucleotide analogue are stable at pH 7.0, even though they contain several C.GC base triplets. These modified triplex-fo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/nar/gkh776
-
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- Journal:
- Nucleic acids research
- Volume:
- 32
- Issue:
- 15
- Pages:
- 4439-4447
- Publication date:
- 2004-01-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:0033337c-2777-47bc-8c84-2401bd53ccd7
- Source identifiers:
-
400050
- Local pid:
- pubs:400050
- Copyright date:
- 2004
Journal article
Selectivity and affinity of triplex-forming oligonucleotides containing 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine for recognizing AT base pairs in duplex DNA.
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