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Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial

Abstract:

Background

The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and β blockers used. For a given reduction in blood pressure, some suggested that newer agents would confer advantages over diuretics and β blockers. Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipi... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Contributor
Publisher:
Elsevier
Journal:
Lancet More from this journal
Volume:
366
Issue:
9489
Pages:
895-906
Publication date:
2005-09-04
DOI:
EISSN:
1474-547X
ISSN:
0140-6736

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