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Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.

Abstract:

Recent evidence supports the strong overlap between genes implicated in monogenic diabetes and susceptibility to type 2 diabetes. Transient neonatal diabetes mellitus (TNDM) is a rare disorder associated with overexpression of genes at a paternally expressed imprinted locus on chromosome 6q24. There are two overlapping genes in this region: the transcription factor zinc finger protein associated with cell cycle control and apoptosis (ZAC also known as PLAGL1) and HYMA1, which encodes an untra...

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Publication status:
Published

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Publisher copy:
10.2337/db06-0216

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Mackay, DJ More by this author
Weedon, MN More by this author
McCarthy, MI More by this author
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Journal:
Diabetes
Volume:
55
Issue:
8
Pages:
2272-2276
Publication date:
2006-08-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:002d9246-5c7a-4d1a-827f-244d8ba48964
Source identifiers:
20083
Local pid:
pubs:20083

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