Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report.

Journal article

This paper reviews the evidence for an association between atypical subtrochanteric fractures and long-term bisphosphonate use. Clinical case reports/reviews and case-control studies report this association, but retrospective phase III trial analyses show no increased risk. Bisphosphonate use may be associated with atypical subtrochanteric fractures, but the case is yet unproven.

Authors: Rizzoli, R; Akesson, K; Bouxsein, M; Kanis, J; Napoli, N

• Journal: Osteoporos Int
• Volume: 22
• Issue: 2
• Pages: 373-390
• Publication date: 2011-02-01
• DOI: 10.1007/s00198-010-1453-5
• EISSN: 1433-2965
• ISSN: 0937-941X
• Language: English
• Keywords: Adult; Bone Density Conservation Agents; Diphosphonates; Aged, 80 and over; Aged; Fractures, Spontaneous; Female; Male; Osteoporosis; Hip Fractures; Humans; Risk; Middle Aged