Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.

Journal article

Authors: McCormack, M; Rabbitts, T

• Journal: New England journal of medicine
• Volume: 350
• Issue: 9
• Pages: 913-922
• Publication date: 2004-02-01
• DOI: 10.1056/nejmra032207
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: T-Lymphocytes; Genetic Diseases, X-Linked; Gene Expression Regulation, Leukemic; Translocation, Genetic; Metalloproteins; Proto-Oncogene Proteins; Severe Combined Immunodeficiency; Receptors, Interleukin-2; Virus Activation; DNA-Binding Proteins; Humans; Oncogenes; Adaptor Proteins, Signal Transducing; LIM Domain Proteins; Leukemia, T-Cell; Genetic Therapy; Gene Expression Regulation; Animals; Retroviridae