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Impaired phagocytic mechanism in annexin 1 null macrophages.

Abstract:

The role of the anti-inflammatory protein annexin-A1 (Anx-A1) in the phagocytic process has been investigated using a murine bone marrow culture-derived macrophage model from Anx-A1(+/+) and Anx-A1(-/-) mice. Macrophages prepared from Anx-A1(-/-) mice exhibited a reduced ingestion of zymosan, Neisseria meningitidis or sheep red blood cells, when compared to Anx-A1(+/+) cells and in the case of zymosan this effect was also mirrored by a reduced clearance in vivo when particles were injected in...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0706730

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
British journal of pharmacology
Volume:
148
Issue:
4
Pages:
469-477
Publication date:
2006-06-01
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Source identifiers:
28018
Language:
English
Keywords:
Pubs id:
pubs:28018
UUID:
uuid:0009a6a3-2d39-4320-a642-3875fe78daef
Local pid:
pubs:28018
Deposit date:
2012-12-19

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