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Journal article

Separation of cancer cells from white blood cells by pinched flow fractionation

Abstract:

In this paper, the microfluidic size-separation technique pinched flow fractionation (PFF) is used to separate cancer cells from white blood cells (WBCs). The cells are separated at efficiencies above 90% for both cell types. Circulating tumor cells (CTCs) are found in the blood of cancer patients and can form new tumors. CTCs are rare cells in blood, but they are important for the understanding of metastasis. There is therefore a high interest in developing a method for the enrichment of CTC...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/C5LC01014D

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering Journal website
Volume:
15
Issue:
24
Pages:
4598-4606
Publication date:
2015-01-01
DOI:
ISSN:
1473-0197
Source identifiers:
571229
Pubs id:
pubs:571229
UUID:
uuid:00070592-e73b-4d8d-833c-a90719c20382
Local pid:
pubs:571229
Deposit date:
2015-11-18

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