Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity.

Journal article

Acromegaly is associated with increased morbidity and mortality unless serum GH levels are persistently less than 5 mU/L ( approximately 2 ng/mL) after treatment. Transsphenoidal surgical resection is the best available treatment for restoring GH to such "safe" levels; however, criteria for the assessment of the response to treatment are not uniform. To determine the clinically most useful method of assessing disease activity postoperatively and identify predictors of a favorable response to ...

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Authors: Kaltsas, G; Isidori, A; Florakis, D; Trainer, P; Camacho-Hubner, C

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 86
• Issue: 4
• Pages: 1645-1652
• Publication date: 2001-04-01
• DOI: 10.1210/jc.86.4.1645
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Prognosis; Adolescent; Postoperative Period; Prolactin; Aged; Tomography, X-Ray Computed; Treatment Outcome; Acromegaly; Pituitary Gland; Adult; Aged, 80 and over; Humans; Human Growth Hormone; Pituitary Neoplasms; Middle Aged; Child