Journal article
The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren
- Abstract:
- Background: Surprisingly little is known about the geographical overlap between malaria and other tropical diseases, including helminth infections. This is despite the potential public health importance of co-infection and synergistic opportunities for control. Methods: Statistical models are presented that predict the large-scale distribution of hookworm in sub-Saharan Africa (SSA), based on the relationship between prevalence of infection among schoolchildren and remotely for Plasmodium falciparum malaria, adjusted for urbanization, the spatial congruence of populations at coincident risk of infection is determined. Results: The model of hookworm indicates that the infection is widespread throughout Africa and that, of the 179.3 million school-aged children who live on the continent, 50.0 (95% CI: 48.9-51-1) million (27% of total population) are infected with hookworm and 45.1 (95% CI: 43.9-46) million are estimated to be at risk of coincident infection. Conclusion: Malaria and hookworm infection are widespread throughout SSA and over a quarter of school-aged children in sub-Saharan Africa appear to be at risk of coincident infection and thus at enhanced risk of clinical disease. The results suggest that the control of parasitic helminths and of malaria in school children could be viewed as essential co-contributors to promoting the health of schoolchildren.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, bin, 77.5KB, Terms of use)
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- Publisher copy:
- 10.1186/1475-2875-5-99
Authors
+ "Wellcome Trust", "Kenyan Medical Research Institute"
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- Funding agency for:
- Snow, R
- Grant:
- 079080
+ "Wellcome Trust, "Albert B. Sabin Vaccine Institute's Human Hookworm Vaccine Initiative (HHVI) funded by the Bill and Melinda Gates Foundation"
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- Funding agency for:
- Brooker, S
- Grant:
- 073656
+ "Schistosomiasis Control Initiative funded by the Bill and Melinda Gates Foundation"
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- Funding agency for:
- Clements, A
- Publisher:
- BioMed Central
- Journal:
- Malaria journal More from this journal
- Volume:
- 5
- Article number:
- 99
- Publication date:
- 2006-11-01
- Edition:
- Publisher's version
- DOI:
- ISSN:
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1475-2875
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:000629ba-705f-4a78-8172-6990f2bb9950
- Local pid:
-
ora:2406
- Deposit date:
-
2008-10-29
- ARK identifier:
Terms of use
- Copyright holder:
- Brooker et al
- Copyright date:
- 2006
- Notes:
- Citation: Brooker, S. et al. (2006). 'The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren', Malaria Journal, 5:99. [This article is available from: http://www.malariajournal.com/content/5/1/99]. Copyright 2006 Brooker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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