Journal article
Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care
- Abstract:
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been shown to be useful for ruling out heart failure in primary care. In this study, we examined the accuracy of the Cobas h232 point-of-care (POC) instrument in primary care compared with an in-hospital measurement. Furthermore, we investigated the user-friendliness and usefulness of the POC device.Five general practitioner (GP) groups were asked to evaluate adult patients who were suspected of having heart failure and to test NT-proBNP with the Cobas h232. The samples were subsequently delivered to and analysed at a central hospital laboratory by the Cobas e602 using conventional transport and storage. Difference between the paired measurements was analysed using a percentage difference plot, and correlation was assessed using Passing-Bablok linear regression analysis. User-friendliness and usefulness were assessed using semistructured questionnaires.Nineteen GPs studied 94 patients. Passing-Bablok analysis showed a slope of 1.05 (95% CI 1.00 to 1.11) (R2=0.97). The percentage difference plot showed a mean difference of 15.7% (95% CI -46.0% to -77.4%). User-friendliness and usefulness had median scores of 4 or 5 on a five-point Likert scale. Eighteen out of 19 GPs confirmed that the device influenced their clinical practice. During the study, GPs' confidence in using NT-proBNP increased significantly from a mean score of 4.4 (95% CI 3.2 to 5.6) to 7.6 out of 10 (95% CI 7.1 to 8.2).The Cobas h232 NT-proBNP POC test proved to be an accurate, user-friendly and useful test in primary care. Nearly all participating GPs were convinced that the test could benefit clinical decision making.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 778.8KB, Terms of use)
-
- Publisher copy:
- 10.1136/jclinpath-2017-204746
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- Journal of Clinical Pathology More from this journal
- Volume:
- 71
- Issue:
- 6
- Pages:
- 539-545
- Publication date:
- 2017-12-20
- Acceptance date:
- 2017-11-23
- DOI:
- EISSN:
-
1472-4146
- ISSN:
-
0021-9746
- Pmid:
-
29263170
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:812361
- UUID:
-
uuid:d73015a8-e230-48dd-80e0-7f18c4d7240d
- Local pid:
-
pubs:812361
- Source identifiers:
-
812361
- Deposit date:
-
2017-12-22
- ARK identifier:
Terms of use
- Copyright holder:
- Hex et al
- Copyright date:
- 2017
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from BMJ Publishing Group at: https://doi.org/10.1136/jclinpath-2017-204746
If you are the owner of this record, you can report an update to it here: Report update to this record