Journal article
Formation of vertebral precursors: past models and future predictions
- Abstract:
- Disruption of normal vertebral development results from abnormal formation and segmentation of the vertebral precursors, called somites. Somitogenesis, the sequential formation of a periodic pattern along the antero-posterior axis of vertebrate embryos, is one of the most obvious examples of the segmental patterning processes that take place during embryogenesis and also one of the major unresolved events in developmental biology. We review the most popular models of somite formation: Cooke and Zeeman's clock and wavefront model, Meinhardt's reaction–diffusion model and the cell cycle model of Stern and co-workers, and discuss the consistency of each in the light of recent experimental findings concerning FGF-8 signalling in the presomitic mesoderm (PSM). We present an extension of the cell cycle model to take account of this new experimental evidence, which shows the existence of a determination front whose position in the PSM is controlled by FGF-8 signalling, and which controls the ability of cells to become competent to segment. We conclude that it is, at this stage, perhaps erroneous to favour one of these models over the others.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1080/10273660310001628365
Authors
- Publisher:
- Hindawi
- Journal:
- Journal of Theoretical Medicine More from this journal
- Volume:
- 5
- Issue:
- 1
- Pages:
- 23-35
- Publication date:
- 2011-08-11
- Acceptance date:
- 2003-07-18
- DOI:
- ISSN:
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1027-3662
- Keywords:
- Pubs id:
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pubs:195574
- UUID:
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uuid:3f844b17-306a-49c3-89e2-ba03669a4818
- Local pid:
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pubs:195574
- Source identifiers:
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195574
- Deposit date:
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2016-08-01
- ARK identifier:
Terms of use
- Copyright holder:
- Hindawi Publishing Corporation
- Copyright date:
- 2011
- Notes:
- Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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