Journal article
Influence of correlated antigen presentation on T-cell negative selection in the thymus
- Abstract:
- The thymus is the primary organ for the generation of naive T cells, a key component of the immune system. Tolerance of T cells to self is achieved primarily in the thymic medulla, where immature T cells (thymocytes) sample self-peptides presented by medullary thymic epithelial cells (mTECs). A sufficiently strong interaction activates the thymocytes leading to negative selection. A key question of current interest is whether there is any structure in the manner in which mTECs present peptides: can any mTEC present any peptide at any time, or are there particular patterns of correlated peptide presentation? We investigate this question using a mathematical model of negative selection. We find that correlated patterns of peptide presentation may be advantageous in negatively selecting low-degeneracy thymocytes (that is, those thymocytes which respond to relatively few peptides). We also quantify the probability that an auto-reactive thymocyte exits the thymus before it encounters a cognate antigen. The results suggest that heterogeneity of gene co-expression in mTECs has an effect on the probability of escape of autoreactive thymocytes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1098/rsif.2018.0311
Authors
- Publisher:
- Royal Society
- Journal:
- Journal of the Royal Society Interface More from this journal
- Volume:
- 15
- Issue:
- 148
- Article number:
- 20180311
- Publication date:
- 2018-11-07
- Acceptance date:
- 2018-09-26
- DOI:
- EISSN:
-
1742-5662
- ISSN:
-
1742-5689
- Keywords:
- Pubs id:
-
pubs:923767
- UUID:
-
uuid:f25cb724-ad2b-47f7-a5dd-8d03bc0478b5
- Local pid:
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pubs:923767
- Deposit date:
-
2018-10-05
Terms of use
- Copyright holder:
- Banerjee and Champman
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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